2021 |2020| 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009

2021

TREAT TB End of Project Report: Generating evidence to improve diagnosis and treatment of tuberculosis

2020

Challenges in Tuberculosis Clinical Trials in the Face of the COVID-19 Pandemic: A Sponsor’s Perspective

Source: Trop. Med. Infect. Dis. 2020 May 27; 5(2), 86
Authors: I.D. Rusen

Economic evaluation of short treatment for multidrug-resistant tuberculosis, Ethiopia and South Africa: the STREAM trial

Source: Bull World Health Organ 2020;98:306–314
Authors: Madan J, Rosu L, Girma Tefera M, et al.

2019

A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis

Source: N Engl J Med. 2019 Mar 13 ; 380:1201-1213
Authors: Nunn A, Phillips P, Meredith S, et al.

Challenges and opportunities to prevent tuberculosis in people living with HIV in low-income countries

Source: The International Journal of Tuberculosis and Lung Disease, Volume 23, Number 2, 1 February 2019, pp. 241-251(11)
Authors: Harries A, Schwoebel V, Monedero-Recuero I, et al.

Modelling the impact of chest X-ray and alternative triage approaches prior to seeking a tuberculosis diagnosis

Source: BMC Infectious Diseases volume 19, Article number: 93 (2019)
Authors: Abu A. M, Rahman S, Langley I, et al.

2018

Tuberculosis in children treated with second-line drugs under programmatic conditions in Lima, Peru

Source: The International Journal of Tuberculosis and Lung Disease, Volume 22, Number 11, 1 November 2018, pp. 1307-1313(7)
Authors: Villarreal J, Alarcón V, Alarcón-Arrascue E, Moore, D, Helda E, Mendoza-Ticona A

Building the evidence base for shortened MDR-TB treatment regimens

Treatment outcomes for isoniazidmonoresistant tuberculosis in Peru

Source: DAJ (2018) 2012-2014. PLoS ONE 13(12)
Authors: Cornejo G, Alarcón Guizado VA, Mendoza Ticona A, Alarcon E, Heldal E, Moore D

Rapid drug susceptibility testing and treatment outcomes for multidrug-resistant tuberculosis in Peru

Source:The International Journal of Tuberculosis and Lung Disease, Volume 22, Number 11, 1 November 2018, pp. 1350-1357(8)
Author: Obregón G, Zevallos K, Alarcón V, et al.

Programmatic management of patients with pre-extensively drug-resistant tuberculosis in Peru, 2011–2014

Source: Int J Tuberc Lung Dis. 2018 Oct 1;22(10):1220-1226
Authors: Alarcón V, Alarcón-Arrascue E, Mendoza-Ticona A, Obregón G, et al.

Shortened treatment regimens versus the standard regimen
for drug-sensitive pulmonary tuberculosis (Protocol)

Source: Cochrane Database of Systematic Reviews 2018, Issue 1. Art. No.: CD012918.
Authors: Grace AG, Mittal A, Jain S, et al.

Cost-effectiveness of GeneXpert and LED-FM for diagnosis of pulmonary tuberculosis: A
systematic review

Source: PLoS ONE 13(10): e0205233 (2018).
Authors: Sagili K, Muniyandi M, Nilgiriwala K, et al.

Coprevalence of type 2 diabetes mellitus and tuberculosis in low‐income and middle‐income countries: A systematic review

Source: Diabetes Metab Res Rev. 2018;e3066 (2018).
Authors: Stowe McMurry H, Mendenhall E, Rajendrakumar A, Nambia L, Satyanarayana S, Shivashankar R

Is Chemoprophylaxis for Child Contacts of Drug-Resistant TB Patients Beneficial? A Systematic Review

Source: Tuberculosis Research and Treatment Volume 2018, Article ID 3905890
Authors: Padmapriyadarsini C, Das M, Nagaraja S, et al.

2017

Protecting those who care for others

Source: Public Health Action, Volume 7, Number 4, 21 December 2017, pp. 244-244(1)
Authors: I.D. Rusen

Risk factors for unfavourable treatment outcome among new smear-positive pulmonary tuberculosis cases in China

Source: Public Health Action, Volume 7, Number 4, 21 December 2017, pp. 299-303(5)
Authors: Lin Y, Enarson D, Du J, Dlodlo R, Chiang C, Rusen I.D

Loss to follow-up among children in pre-ART care under the National AIDS Programme, Tamil Nadu, South India

Source: Public Health Action. 2017 Jun 21; 7(2): 90–94.
Authors: Devi N, Kumar A, Chinnakali P, Rajendran M, Valan A, Rewari B, Swaminathan S

Effect of glycemic control and type of diabetes treatment on unsuccessful TB treatment
outcomes among people with TB-Diabetes: A systematic review

Source: PLoS ONE 12(10): e0186697. (2017)
Authors: Shewade H, Jeyashree K, Mahajan P, et al.

Outcomes from patients with presumed drug resistant tuberculosis in five reference centers in Brazil

Source: BMC Infectious Diseases (2017) 17:571
Authors: Ramalho D, Miranda P, Andrade M, et al.

Operational modelling: the mechanisms influencing TB diagnostic yield in an XpertW MTB/RIF-based algorithm

Source: INT J TUBERC LUNG DIS 21(4):381–388 (2017)
Authors: Dunbar R, Naidoo P, Beyers N, Langley I

Economic evaluation of a shortened standardised treatment regimen of antituberculosis drugs for patients with multidrug-resistant tuberculosis (STREAM): study protocol.

Source: BMJ Open. 2016 Oct 17; 6(10): e014386. Authors: Gama E, Madan J, Langley I, Girma M, Evans D, Rosen S, Squire SB.

2016

“When Treatment Is More Challenging than the Disease”: A Qualitative Study of MDR-TB Patient Retention.

Source: PLoS One. 2016 Mar 9;11(3):e0150849.
Authors: Shringarpure KS, Isaakidis P, Sagili KD, Baxi RK, Das M, Daftary A

Pediatric multidrug-resistant tuberculosis clinical trials: challenges and opportunities

Source: Int J Infect Dis. 2017 Mar;56:194-199
Authors: McAnaw S, Hesseling A, Seddon J, et al.

Optimizing MDR-TB clinical trials: insights from the first global MDR-TB Clinical Trials Landscape Meeting

Source: The International Journal of Tuberculosis and Lung Disease, Volume 20, Supplement 1, 1 December 2016, pp. S1-S3(3)
Authors: Horsburgh, C. Robert; Rusen, I. D.; Mitnick, Carole D.

Health service perceptions about implementation of a new TB diagnostic in Northern Russia: a qualitative study

Source: Public Health Action, Volume 6, Number 3, 21 September 2016, pp. 181-189(9)
Authors: Kuznetsov V, Bissell K

Comparing laboratory costs of smear/culture and XpertW MTB/RIF-based tuberculosis diagnostic algorithms

Source: INT J TUBERC LUNG DIS 20(10):1377–1385 (2016)
Authors: Naidoo P, Dunbar R, du Toit E, van Niekerk M, Squire S, Beyers N, Madan J

Economic evaluation of a shortened standardised treatment regimen of antituberculosis drugs for patients with multidrug-resistant tuberculosis (STREAM): study protocol

Source: BMJ Open 2016; 6:e014386.
Authors: Zachariah R, Harries D, Ishikawa N, et al.

Comparing Tuberculosis Diagnostic Yield in Smear/Culture and Xpert1 MTB/RIF-Based Algorithms Using a Non-Randomised Stepped-Wedge Design

Source: PLoS ONE 11(3): e0150487 (2016).
Authors: Naidoo P, Dunbar R, Lombard C, du Toit E, Caldwell J, Detjen A, et al.

Latent Tuberculosis Infection Diagnostic and Treatment Cascade among Contacts in Primary Health Care in a City of Sao Paulo State, Brazil: Cross-Sectional Study

Source: PLoS ONE 11(6): e0155348. (2016)
Authors: Wysocki AD, Villa TCS, Arakawa T, Brunello MEF, Vendramini SHF, Monroe AA, et al.

2015

Intensified tuberculosis case finding amongst vulnerable communities in southern India

Source: Public Health Action. 2015 Dec 21; 5(4): 246–248.
Authors: Reddy K, Ananthakrishnan R, Jacob A, Das M, Isaakidis P, Kumar A

Developments in Impact Assessment of New Diagnostic Algorithms for Tuberculosis Control

Source: Clinical Infectious Diseases, Volume 61, Issue suppl_3, 15 October 2015
Authors: Langley I, Squire B, Dacombe R, et al.

Capacity building in operational
research: more than one way to slice the cake

Source: Front. Public Health, 09 July 2015
Authors: Rusen I. D, Harries A, Zachariah R, Ramsay A

Reasons for the low bacteriological coverage of tuberculosis reported in Mpumalanga Province, South Africa

Source: Public Health Action, Volume 5, Number 2, 21 June 2015, pp. 122-126(5)
Authors: Mngomezulu N, Cameron D, Olorunju S, Luthuli T, Dunbar R, Naidoo P

MDR-TB screening in a setting with molecular diagnostic techniques: who got tested, who didn’t and why?

Source: Public Health Action, Volume 5, Number 2, 21 June 2015, pp. 132-139(8)
Authors: Shewade H, Govindarajan S, Sharath B, et al.

Operational research in low income countries: what, why and how?

Source: Public Health Action. 2015 Mar 21; 5(1): 59–64.
Authors: Tripathi U, Nagaraja S, Tripathy J, et al.

Patient delay in the diagnosis and treatment of tuberculosis in China: findings of case detection projects

Source: Public Health Action, Volume 5, Number 1, 21 March 2015, pp. 65-69(5)
Authors: Lin Y, Enarson D, Chiang C-Y, et al.

Capacity building in operational research: more than one way to slice the cake.

Source: Front. Public Health 3:176. (2015)
Authors: Rusen ID, Harries AD, Zachariah R and Ramsay A

Comparing multidrug-resistant tuberculosis patient costs under
molecular diagnostic algorithms in South Africa

Source: INT J TUBERC LUNG DIS 19(8):000–000 (2015)
Authors: du Toit E, Squire S, Dunbar R, et al.

Has introduction of rapid drug susceptibility testing at diagnosis impacted treatment outcomes among previously treated tuberculosis patients in Gujarat, India?

Source: PLoS ONE 10(4): e0121996. (2015)
Authors: Dave P, Vadera B, Kumar A, et al.

TB Treatment Delays in Odisha, India: Is It Expected Even after These Many Years of RNTCP Implementation?

Source:  PLoS ONE 10(4): e0125465. (2015)
Authors: Ilangovan K, Burugina Nagaraja S, Ananthakrishnan R, Jacob A, Tripathy J, Tamang D

“They Know, They Agree, but They Don’t Do”- The Paradox of Tuberculosis Case Notification by Private Practitioners in Alappuzha District, Kerala, India

Source:  PLoS ONE 10(4): e0123286. (2015)
Authors: Philip S, Isaakidis P, Sagili KD, Meharunnisa A, Mrithyunjayan S, Kumar AMV 

Loss-To-Follow-Up on Multidrug Resistant Tuberculosis Treatment in Gujarat, India: The WHEN and WHO of It

Source: PLoS ONE 10(7): e0132543. (2015)
Authors: Shringarpure KS, Isaakidis P, Sagili KD, Baxi RK

Pathways to multidrug-resistant
tuberculosis diagnosis and treatment initiation: a qualitative comparison of patients’ experiences in the era of rapid molecular diagnostic tests

Source: BMC Health Services Research (2015) 15:488
Authors: Naidoo P, Niekerk M, du Toit E, Beyers, and Leon N

The complex relationship between human immunodeficiency virus infection and death in adults being treated for tuberculosis in Cape Town, South Africa

Source: BMC Public Health (2015) 15:556
Authors: Osman M, Seddon J, Dunbar R, et al.

Global-to-local policy transfer in the introduction of new molecular tuberculosis diagnostics in South Africa

Source: INT J TUBERC LUNG DIS 19(11):1326–1338 (2015)
Authors: Colvin C, Leon N, Wills C, van Niekerk M, Bissell K, Naidoo P

2014

Number of sputum specimens during treatment follow-up of tuberculosis patients: two or one?

Source: Public Health Action. 2014 Dec 21; 3(4): 304–307.
Authors: Kumar R, Kumar A, Claassens M, et al.

Symptom reporting among prevalent tuberculosis cases who smoke, are HIV-positive or have hyperglycaemia

Source: Public Health Action, Volume 4, Number 4, 21 December 2014, pp. 222-225(4)
Authors: Sattar S, Van Schalkwyk C, Claassens M, et al.

Factors influencing increased expertise for a sustainable workforce at a research centre in South Africa

Source: Public Health Action, Volume 4, Number 4, 21 December 2014, pp. 276-280(5)
Authors: Brand S, Draper H, Enarson D, Beyers N, Claassens M

TREAT TB Description of Research Outputs, 2009 – 2014

Operational modelling to guide implementation and scale-up of diagnostic tests within the health system: exploring opportunities for parasitic disease diagnostics based on example application for tuberculosis

Source: Parasitology. 2014 Dec;141(14):1795-802.
Authors: Langley I, Adams E, Doulla B, Squire SB

Assessment of the patient, health system, and population effects of Xpert MTB/RIF and alternative diagnostics for tuberculosis in Tanzania: an integrated modelling approach.

Source: Lancet Glob Health. 2014 Oct;2(10):e581-91.
Authors: Langley I, Lin HH, Egwaga S, et al.

A Comparison of Multidrug-Resistant Tuberculosis Treatment Commencement Times in MDRTBPlus Line Probe Assay and XpertH MTB/RIF-Based Algorithms in a Routine Operational Setting in Cape Town

Source: PLoS One. 2014 Jul 31;9(7):e103328
Authors: Naidoo P, du Toit E, Dunbar R, et al.

Same-day light-emitting diode fluorescence microscopy for the diagnosis of tuberculosis in Chhattisgarh, India

Source: The International Journal of Tuberculosis and Lung Disease, Volume 18, Number 6, 1 June 2014, pp. 666-670(5)
Authors: Nayak P, Kumar A, Agrawal T, Chandraker S, Nair S

Missed opportunities for retention in pre-ART care in Cape Town, South Africa.

Source: PLoS One. 2014 May 7;9(5):e96867
Authors: du Toit E, van Schalkwyk C, Dunbar R, et al.

Are we justified in treating for multidrug-resistant tuberculosis based on positive follow-up smear results?

Source: The International Journal of Tuberculosis and Lung Disease, Volume 18, Number 4, 1 April 2014, pp. 449-453(5)
Authors: Kumar R, Kumar A, Claassens M, et al.

Sex-related trends in non-conversion of new smear-positive tuberculosis patients in the Free State, South Africa

Source: Public Health Action, Volume 4, Number 1, 21 March 2014, pp. 66-71(6)
Authors: Heunis J, Kigozi N, van der Merwe S, Chikobvu P, Beyers N

Determinants of tuberculosis treatment completion among newborns in a high-burden setting

Source: The International Journal of Tuberculosis and Lung Disease, Volume 18, Number 3, 1 March 2014, pp. 335-340(6)
Authors: Bekker A, Slogrove A, Schaaf H, Du Preez K, Hesseling A

Integration of TB and ART services fails to improve TB treatment outcomes: comparison of ART/TB primary healthcare services in Cape Town, South Africa.

Source: S Afr Med J. 2014 Mar;104(3):204-9.
Authors: Kaplan R, Caldwell J, Bekker LG, et al.

Characteristics of clients who access mobile compared to clinic HIV counselling and testing services: a matched study from Cape Town, South Africa

Source: BMC Health Services Research 2014, 14:658.
Authors: Meehan S, Naidoo P, Claassens M, Lombard C, and Beyers N

2013

Pretreatment sputum smear grade and smear positivity during follow-up of TB patients in Ahmedabad, India [Short communication]

Source: Public Health Action, Volume 3, Number 4, 21 December 2013, pp. 308-310(3)
Authors: Patel J, Dave P, Satyanarayana S, et al.

A comparative study of tuberculosis patients initiated on ART and receiving different models of TB-HIV care

Source: The International Journal of Tuberculosis and Lung Disease, Volume 17, Number 12, 1 December 2013, pp. 1558-1563(6)
Authors: Schulz S, Draper H, Naidoo P

Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India.

Source: PLoS One. 2013 Oct 14;8(10):e76275
Authors: Nandakumar KV, Karthickeyan Duraisamy, Shibu Balakrishnan, et al.

The Impact of Isoniazid Resistance on the Treatment Outcomes of Smear Positive Re-Treatment Tuberculosis Patients in the State of Andhra Pradesh, India

Source: PLoS One. 2013 Oct 11;8(10):e76189.
Authors: Deepa D, Achanta S, Jaju J, Rao K, Samyukta R, Claassens M, Kumar AM, Ph V.

LED-fluorescence microscopy for diagnosis of pulmonary tuberculosis under programmatic conditions in India.

Source: PLoS One. 2013 Oct 9;8(10):e75566
Authors: Reza LW, Satyanarayna S, Enarson DA, Kumar AM, et al.

Comparing same day sputum microscopy with conventional sputum microscopy for the diagnosis of tuberculosis–Chhattisgarh, India.

Source: PLoS One. 2013 Sep 23;8(9):e74964.
Authors: Nayak P, Kumar A, Claassens M, et al.

Is physical access an impediment to tuberculosis diagnosis and treatment? A study from a rural district in North India

Source: Public Health Action, Volume 3, Number 3, 21 September 2013, pp. 235-239(5)
Authors: Tripathy J, Srinath S, Naidoo P, Ananthakrishnan R, Bhaskar R

Routine programmatic delivery of isoniazid preventive therapy to children in Cape Town, South Africa

Source: Public Health Action, Volume 3, Number 3, 21 September 2013, pp. 199-203(5)
Authors: Osman M, Hesseling A, Beyers N, et al.

Tuberculosis cases missed in primary health care facilities: should we redefine case finding?

Source: INT J TUBERC LUNG DIS 17(5):608–614
Authors: Claassens M, Jacobs E, Cyster E, et al.

Effectiveness of a community-based observation of anti-tuberculosis treatment in Bangalore City, India, 2010–2011

Source: Public Health Action, Volume 3, Number 3, 21 September 2013, pp. 230-234(5)
Authors: Tripathy S, Kumar P, Sagili K, Enarson D

Uptake of HIV testing and HIV positivity among presumptive tuberculosis patients at Puducherry, South India

Source: Public Health Action, Volume 3, Number 3, 21 September 2013, pp. 220-223(4)
Authors: Palanivel C, Kumar A, Mahalakshmi T, et al.

How Methodologic Differences Affect Results of Economic Analyses: A Systematic Review of Interferon Gamma Release Assays for the Diagnosis of LTBI

Source: PLoS One. 2013;8(3):e56044
Authors: Oxlade O, Pinto M, Trajman A, Menzies D.

2012

Microcolony culture techniques for tuberculosis diagnosis: a systematic review

Source: The International Journal of Tuberculosis and Lung Disease, Volume 16, Number 1, 1 January 2012, pp. 16-23(8)
Authors: Leung E, Minion J, Benedetti A, Pai M, Menzies D

The impact of new tuberculosis diagnostics on transmission: why context matters

Source: Bull World Health Organ. 2012 Oct 1;90(10):739-747A
Authors: Lin HH, Dowdy D, Dye C, Murray M & Cohen T

High prevalence of tuberculosis and serious bloodstream infections in ambulatory individuals presenting for antiretroviral therapy in Malawi.

Source: PLoS One. 2012;7(6):e39347
Authors: Bedell R, Anderson S, van Lettow M, et al.

The rate of sputum smear-positive tuberculosis after treatment default in a high-burden setting: a retrospective cohort study.

Source: PLoS One. 2012;7(9):e45724
Authors: Marx F, Dunbar R, Enarson D, Beyers N

The rate of sputum smear-positive tuberculosis after treatment default in a high-burden setting: a retrospective cohort study.

Source: Health Care Manag Sci (2012) 15:239–253
Authors: Langley I, Doulla B, Lin HH,
Millington K, Squire B

2011

Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis.

Source: Int J Tuberc Lung Dis. 2011 Aug;15(8):1018-32
Authors: Mandalakas A, Detjen A, Hesseling A, Benedetti A, Menzies D

A modelling framework to support the selection and implementation of new tuberculosis diagnostic tools [State of the art series. Operational research. Number 8 in the series]

Source: The International Journal of Tuberculosis and Lung Disease, Volume 15, Number 8, August 2011, pp. 996-1004(9)
Authors: Lin HH, Langley I, Mwenda R, et al.

Making innovations accessible to the poor through implementation research.

Source: Int J Tuberc Lung Dis. 2011 Jul;15(7):862-70
Authors: Squire S, Ramsay A, van den Hof S, et al.

Making innovations accessible to the poor through implementation research.

Source: PLoS One. 2011; 6(12):
Authors: Tweya H, Kanyerere H, Ben-Smith A, et al.

Diagnosing tuberculosis with urine lipoarabinomannan: systematic review and meta-analysis

Source: European Respiratory Journal 2011 38: 1398-1405
Authors: Minion, Leung E, Talbot E, Dheda K, Pai M, Menzis D

Analysing policy transfer: perspectives for operational research

Source: INT J TUBERC LUNG DIS 15(9):1140–1148 (2011)
Authors: Bissell K, Lee K, Freeman R

The Union and Médecins Sans Frontières approach to operational research

Source: INT J TUBERC LUNG DIS 15(2):144–154 (2011)
Authors: Harries A, Rusen I.D, Reid T, et al.

Tuberculosis ‘retreatment others’: profile and treatment outcomes in the state of Andhra Pradesh, India

Source: INT J TUBERC LUNG DIS 15(1):105–109 (2011)
Authors: Srinath S, Sharath B, Santosha K, et al.

Source of Previous Treatment for Re-Treatment TB Cases Registered under the National TB Control Programme, India, 2010

Source: PLoS ONE 6(7): e22061. (2011)
Authors: Sachdeva K, Satyanarayana S, Dewan P, et al.

Operational research on operational research:
much more to be learned

Source: INT J TUBERC LUNG DIS 15(11):1421 (2011)
Authors: I. D. Rusen

The Union and Médecins Sans Frontières approach to operational research

Source: INT J TUBERC LUNG DIS 15(2):144–154 (2011)
Authors: Harries A, Rusen I.D, Reid T, et al.

2010

Short, Highly Effective, and Inexpensive Standardized Treatment of Multidrug-resistant Tuberculosis

Source: Am J Respir Crit Care Med. 2010 Sep 1;182(5):684-92
Authors: Van Deun A, Maug AK, Salim MA, Das PK, Sarker MR, Daru P, Rieder HL.

Beyond accuracy: creating a comprehensive evidence base for tuberculosis diagnostic tools

Source: INT J TUBERC LUNG DIS 14(12): 1518–1524 (2010)
Authors: Mann G, Squire S, Bissell K, et al.

2009

Operational research in low income countries: what, why and how?

Source: Lancet Infect Dis 2009; 9:7-717.
Authors: Zachariah R, Harries D, Ishikawa N, et al.