TREAT TB highlights its work at this year’s World Conference on Lung Health

Over 4,000 delegates from around the world attended The Union’s 49th World Conference on Lung Health and participated in a four-day scientific program of plenary sessions, symposia, panel discussions, and poster presentations.

This conference provided an excellent opportunity for international representatives of the TREAT TB project to share progress made, discuss best practices and lessons learned with global tuberculosis (TB) stakeholders.

TREAT TB hosted a number of sessions including:

 The sessions touched on three key aspects of TREAT TB’s work:

  • Clinical research

  • Capacity building and

  • Community engagement

 STREAM investigators answer questions from the audience about STREAM Stage 1 final results.

STREAM investigators answer questions from the audience about STREAM Stage 1 final results.

TREAT TB closed the conference by providing an update on the STREAM trial. The STREAM trial aims to generate evidence regarding the safety and effectiveness of shorter, more tolerable MDR-TB regimens, while also improving local capacity to conduct clinical trials. Evidence generated by this trial has and will continue to contribute to development of international and national treatment guidelines. During TREAT TB’s final session of the conference, STREAM partners, including Vital Strategies, The Medical Research Counsel at University College London, and the Liverpool School of Tropical Medicine, discussed STREAM Stage 1 results and implications for the implementation of the shortened regimen. To read more about the STREAM trial, click here.

 

 Attendees capture key information from symposium on clinical trial capacity building for MDR-TB clinical trials.

Attendees capture key information from symposium on clinical trial capacity building for MDR-TB clinical trials.

TREAT TB’s session on capacity building for MDR-TB clinical trials provided the opportunity for experts to discuss the current landscape for TB clinical trials, focusing on key issues currently affecting clinical trial capacity. Speakers from around the world addressed topics ranging from supply chain management to mycobacteriology laboratory capacity to community engagement in MDR-TB clinical trials. They highlighted progress to date, current challenges and possible ways to improve capacity for conducting clinical trials, drawing on their experience with the STREAM Clinical Trial and other TB research ongoing in their countries.  To read more about the capacity building work carried out by TREAT TB, click here.

A common message repeated in each of TREAT TB’s sessions, and the sentiment echoed in discussion with participants, was that community engagement is integral to the successful implementation of clinical research. Presenters and participants alike also agreed on the vital role played by community advisory boards (CABs) to ensure that communities and stakeholders understand the trial process and take ownership. CABs also act as a critical link between affected communities and trial staff, sharing community views on key implementation issues.

 Participants fully engaged in with panelists regarding challenges and solutions for improved dissemination of clinical trial results.

Participants fully engaged in with panelists regarding challenges and solutions for improved dissemination of clinical trial results.

During TREAT TB’s panel discussion on the dissemination of clinical trial results, Ezio Tavora Dos Santos Filho, the STREAM Community Engagement Coordinator from REDE-TB discussed community engagement as a ‘mechanism of accountability’ which ensures that trials and study teams are held accountable to governments, donors, and above all, trial participants. To read more about TREAT TB and STREAM’s work in community engagement, click here.

 

You can find more information on the Union’s 49th Conference on Lung Health here.

TREAT TB team travels to The Hague for the World Conference on Lung Health

This week, members of the TREAT TB team will travel to The Hague to participate in The Union’s 49th World Conference on Lung Health (WCLH). This will be an excellent opportunity to provide an update on progress made, share experiences and lessons learned, and discuss final results from Stage 1 of the STREAM Clinical Trial.

The team will host and participate in a number of sessions during the WCLH, including…

Importance of community engagement in the STREAM clinical trial

Subrat Mohanty, the STREAM community engagement coordinator in India, will present his experiences of community engagement at two STREAM trial sites. STREAM Stage 2 is working in India to evaluate the safety and effectiveness of an all-oral nine-month regimen for multidrug-resistant tuberculosis (MDR-TB). This session will outline the key community engagement milestones achieved at the India sites during the first year of the trial. To find more information on this session, click here.

Clinical trial capacity building to address multidrug-resistant tuberculosis: challenges and the way forward

TREAT TB will hold a symposium to explore challenges and best practices in connection with MDR-TB clinical trials. Presentations will include:

  • MDR-TB clinical trial landscape overview, Robert Horsburgh Jr., United States of America

  • Ethics and regulatory capacity building, Abraham Aseffa, Ethiopia

  • Challenges and efforts in strengthening capacity of site pharmacies and pharmacists in the STREAM Trial, Jan Komrska, United States of America

  • Mycobacteriology laboratory capacity building for tuberculosis clinical trials, Gomathi N.S., India

  • Community engagement in MDR-TB clinical trials, Ezio Tavora, Brazil

To find more information on this symposium, click here.

Improving dissemination of clinical trial results – experiences in TB and HIV clinical trials

TREAT TB will facilitate a panel discussion focused on improving dissemination of clinical trial results. The panel discussion will include experts in communications, community engagement and clinical trials, with experience in both HIV and TB clinical trials. Panelists for this event will tackle issues such as making complex information accessible to all audiences, how to communicate sensitive issues, such as unfavorable or unexpected outcomes, and using results to advocate for change. You can find more information on this panel discussion here.

Final STREAM Stage 1 results with implications for implementation

TREAT TB will present the STREAM Stage 1 results and discuss implications for the implementation of the shortened regimen. The trial’s key partners, including Vital Strategies, The Medical Research Counsel at University College London and the Liverpool School of Tropical Medicine will participate in this symposium. Learn more about this symposium here.

You can find more information about the STREAM trial here.